The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

The global pandemic needs to mark a turning point for the peoples of Aotearoa New Zealand. How can we make sure that our culturally diverse nation charts an equitable and sustainable path through and beyond this new world? In a less affluent future, how can we ensure that all New Zealanders have fair access to opportunities? One challenge is to preserve the sense of common purpose so critical to protecting each other in the face of Covid-19. How can we centre (...) what we have learnt about resilience within Māori and wider Pacific communities in our reforms? How can public understanding of Covid-19 science create a platform for the future social valuing of expertise? How can we ensure that the impact of Covid-19 in New Zealand results in a more sustainable, and inclusive workforce–for instance by expanding our perceptions of the value of our workers through promoting digital inclusion? To meet these challenges, we must reimagine our existing traditions of thought, breathing new life into perennial concepts and debates. Our paper indicates some of the ways that Philosophy is central to this collective reimagining, highlighting solutions to be found across our rich philosophical traditions. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The sensorimotor account of vision proposed by O'Regan & Noë (O&N) challenges the classical view of visual cognition as a process of mentally representing the world. Many infant cognition researchers would probably disagree. I describe the surprising ability of young infants to represent and reason about the physical world, and ask how this capacity can be explained in non-representational terms. As a first step toward answering this question, I suggest that recent models of embodied cognition may help illustrate a way (...) of escaping the representational trap. (shrink)

Henüz çok az çalışılmış veba risaleleri on dördüncü yüzyılın ortasındaki Kara Ölüm kıyametinden sonra yüzyıllarca tekrarlayan salgınlarla Batı Avrasya’yı kasıp kavuran kültürel dönüşümlere tanıklık eder. Bu türe Osmanlı katkıları, emperyal-bilimsel erken modernitenin ortaya çıkışını izlememize olanak sağlaması açısından örneklik teşkil eder. Bu makale bilinen en kapsamlı ve yenilikçi İslami veba risalesini, Taşköprîzâde Ahmed’in (ö.1561) Risâletü’ş-Şifâ’sını sunmaktadır. Bu eserde ünlü Osmanlı hezarfeni, hem dinî hem rasyonel argümanlar takdim ederek okült bilimin vebayı önlemede ve tedavi etmede en deneysel yöntem olduğuna dair çok (...) güçlü bir argüman oluşturur. Bu amaçla, eserin teorik ilk yarısını tevekkülü tesebbübe veya kör inancı “bilimsel yöntem”e tercih eden kaderci âlimlerin ve sûfîlerin eleştirisine ayırır; uygulamaya dair olan ikinci yarı ise yaşadığı dönemin tıbbi olarak en etkili bilimsel disiplini olduğunu düşündüğü, genel olarak Batı erken modernitesinin “kozmolojik tahayyül”ünü kapsayan, dünyanın pek çok düşünür ve fail tarafından matematiksel ve dolayısıyla sihirli bir şekilde izlenebilen bir metin olarak görüldüğü Yeni Pisagorcu bir bilim olan harfîliğe (ilm-i hurûf) ayrılmıştır. Okült bilimden hoşnutsuzluğumuza rağmen, Taşköprîzâde burada bir başka erken modern deneyimci olarak adlandırılmalıdır. (shrink)

Bu Araştırma, esas olarak İngiltere, Fransa ve Almanya'da yetişen Avrupa'nın erken aydınlanmasının dini ve felsefi düşüncelerinin doğasının bir araştırmasını yapmayı amaçlamaktadır. 17. yüzyılın sonu ve 18. yüzyılın başlangıcında İngiltere'de başlayan deistik düşünce hareketi, Matthew Tindal örnek alınarak özel olarak incelenmiştir. Tindal tarafından yapılmış orijinal eserler ve onun hakkında ikincil yazılar olan birincil kaynaklar, Tindal'ın Şanlı Devrim sonrası siyaset kurumunun bir destekçisi ve devrim öncesi sosyal, dini ve siyasi düzenin özellikle Katolik Hıristiyanlığın eleştirmeni olduğu sonucuna varmamıza yol açabilir. O Zamanın (...) felsefi ve dini sorularının çoğu için kendi deist yorumunu yaptı. Bu, esas olarak, Yaratılış Kadar Eski Hristiyanlık: Doğal Dinin Yeniden Yayınlanmasının İncili adlı ana çalışmasında gözlemlendi; burada akıl ve doğa yasaları, Hristiyanlığın temel öğretilerini eleştirmek ve reddetmek için kendi başlarına kullanılır. Bu, genel olarak İngiliz deistlerinin ve özellikle Matthew Tindal'ın akıl ve doğal dinin veya doğa yasalarının bizi ateistlerin şüpheciliğini ve nihilizmini veya kendilerini Hristiyan deist olarak adlandıran protestanları veya İslam'ınki gibi başka bir dini örtbas etmeye yönlendirdiğini ima eder. (shrink)

What makes teaching a moral endeavor? How can we prepare classroom practitioners for engaging in that moral endeavor in meaningful and effective ways? This volume brings together leading scholars who draw upon both their academic expertise and substantial wisdom of practice to offer a variety of perspectives on the challenge of preparing today’s teachers for the moral work of teaching. Book Features: Examines the role that teacher preparation and development can play in addressing the moral work of teaching. Highlights the (...) work of leading scholars from educational psychology, educational philosophy, and teacher education. Provides compelling insights for identifying the next generation of our nation’s best teachers. Contributors: Wolfgang Althof, Karen Benson, Marvin Berkowitz, Donald Blumenfeld-Jones, Elizabeth Campbell, Julie Canniff, Mary Crawford, Lana Daly, Rebecca Evers, Catherine Fallona, Gary Fenstermacher, Anthony Holter, Lisa Johnson, Daniel Lapsley, Darcia Narvaez, Virginia Navarro, Larry Nucci, Joy Pelton, Virginia Richardson, Don Senneville, David Light Shields, Barbara Stengel, Jonatha Vare, Marilyn Watson. (shrink)

Uslovii︠a︡ absoli︠u︡tnogo dobra -- Kharakter russkogo naroda.

It has long been believed that membrane proteins present in degradative compartments such as endolysosomes or vacuoles would be destined for destruction. Now however, it appears that mechanisms and machinery exist in simple eukaryotes such as yeast and more complex organisms such as mammals that can rescue potentially “doomed” membrane proteins by retrieving them from these “late” compartments and recycling them back to the Golgi complex. In yeast, a sorting nexin dimer containing Snx4p can recognize and retrieve the Atg27p membrane (...) protein while in mammals, the AP5 complex (with SPG11 and SPG15) directs the recycling of Golgi‐localized proteins along with the cation‐independent mannose 6‐phosphate receptor (CIMPR). Although the respective machinery is different, there is much commonality between yeast and mammals regarding the mechanisms of retrieval and the physiological importance of these late recycling pathways. (shrink)

Byrne (2005) assumes that counterfactual thinking requires a comparison of facts with an imagined alternative. In our view, however, this assumption is unnecessarily restrictive. We argue that individuals do not necessarily engage in counterfactual simulations exclusively to evaluate factual reality. Instead, comparative evaluation is often suspended in favor of experiencing the counterfactual simulation as if it were real.